Ketamine Infusions

Ketamine

Over the past two decades, ketamine therapy has gained recognition for its potent antidepressant effects and ability to alleviate symptoms of various mental health conditions and chronic pain. Originally used as a sedative, ketamine has become a valuable treatment option because it can produce rapid and significant changes in patients.

In contrast to traditional medications like antidepressants, which may take months to take effect, ketamine therapy has been shown to offer relief to patients within a short period of time, with some individuals experiencing improvement after their first treatment session. The mechanisms behind this rapid response are not fully understood, but it is thought to be due to ketamine’s influence on multiple aspects of psychology and physiology.

Intramuscular & Intravenous

Intramuscular (IM) ketamine and intravenous (IV) ketamine are two different medication administration routes. Here are some key differences between the two:

  • Route of administration: IM ketamine is injected into a muscle, while IV ketamine is injected into a vein.
  • The onset of action: IV ketamine tends to work faster than IM ketamine, with the effects starting within minutes of administration. IM ketamine may take longer to take effect, with the effects starting within 30 minutes to an hour after injection.
  • Duration of action: The effects of IV ketamine tend to be shorter-lasting compared to IM ketamine, with the effects typically lasting for 1-2 hours. The effects of IM ketamine can last for up to 8 hours.
  • Side effects: Both IV and IM ketamine can cause side effects, such as dizziness, nausea, and vomiting. However, the frequency and severity of these side effects may differ between the two routes of administration.
  • Dosing: The dosing for IV and IM ketamine may vary based on the specific condition being treated and the individual patient. It is important to follow the dosing recommendations of a healthcare provider to minimize the risk of adverse effects.
  • Suitability: Both IV and IM ketamine can effectively treat certain conditions, but one may be more suitable for a particular patient depending on their specific needs and circumstances. These options will be discussed during your consultation.

Our clinic is pleased to offer a synergistic combination therapy, in addition to ketamine-specific infusions, that includes magnesium sulfate, B complex and B12, NAD+. This approach is designed to enhance the positive outcomes of the therapy. We invite you to speak with our medical team to assess the suitability of this therapeutic option for your individual needs.

The Science

According to recent research, ketamine may exert its effects by inhibiting the NMDA receptor in the lateral habenula, a brain region that processes negative rewards or negative cause-and-effect relationships. People with conditions such as depression and anxiety often exhibit excessive burst firing of the NMDA receptor in the lateral habenula. Likewise, many people with chronic pain exhibit overactivity in NMDA receptors throughout the central nervous system.

As a non-competitive NMDA antagonist, ketamine blocks glutamate from activating the NMDA receptor, which may result in an accumulation of free glutamate that activates the AMPA receptors. When the AMPA receptors are activated by excess glutamate, they release the chemical brain-derived neurotrophic factor (BDNF), which, in combination with the mammalian target of rapamycin (mTOR), promotes the growth of new neural connections. This process of neuroplasticity may help redirect the brain away from hyperactive areas associated with negative reward signals, providing long-term relief for mental health and chronic pain conditions.

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