Depression Treatment

Depression is the leading cause of disability worldwide

Depression is a common and debilitating mental health condition affecting many people in the United States. According to the National Institute of Mental Health (NIMH), an estimated 16.2 million adults in the country experienced at least one major depressive episode in 2016, representing 6.7% of the adult population. Young adults are particularly at risk for depression, with 8.3% of those aged 18 to 25 experiencing at least one major depressive episode in 2016, the highest rate among all age groups. These statistics highlight the significant burden that depression places on individuals and communities and the importance of finding effective treatments for this condition.

How Do You Know If You're Depressed?

There are several common symptoms of depression, including :

  • Persistent feelings of sadness, hopelessness, and worthlessness
  • Loss of interest in previously enjoyable activities
  • Changes in appetite and sleep patterns
  • Fatigue and decreased energy
  • Difficulty concentrating and making decisions
  • Irritability and restlessness
  • Physical symptoms, such as muscle aches, headaches, and stomach problems
  • Thoughts of self-harm or suicide

It’s also important to remember that everyone experiences depression differently. Some people may have only a few symptoms, while others may have many. The severity and frequency of symptoms can also vary from person to person.

If Depression Goes Untreated

Untreated depression can have serious and long-term consequences, including:

  • Increased risk of self-harm and suicide: Depression is a major risk factor for self-harm and suicide. If left untreated, it can increase the likelihood of self-destructive behaviors, such as cutting or overdosing. In severe cases, it can lead to suicidal thoughts, which can be life-threatening if not promptly addressed.
  • Physical health problems: Depression can also negatively impact physical health, increasing the risk of heart disease, stroke, and other chronic illnesses. It can also cause changes in appetite and sleep patterns, leading to weight gain or loss and difficulty sleeping, affecting overall health and well-being.
  • Social isolation: Depression can cause people to lose interest in social activities and withdraw from their friends and family, leading to feelings of loneliness and isolation that can exacerbate the symptoms of depression.
  • Difficulty with work and school: Depression can impair a person’s ability to concentrate and make decisions, making it challenging to perform well at work or school. This can lead to problems with job performance, academic achievement, and relationships with coworkers and classmates.

How Does Ketamine Treat Depression?

Recent evidence suggests that ketamine may have inhibitory effects on the NMDA receptor in the lateral habenula, a brain region involved in processing negative rewards or negative cause-and-effect relationships. People with conditions such as depression and anxiety often exhibit excessive burst firing in the lateral habenula. As a non-competitive NMDA antagonist, ketamine prevents glutamate from activating the NMDA receptor.

This inhibition may result in an accumulation of free glutamate that activates the AMPA receptors. When the AMPA receptors are activated by excess glutamate, they release the chemical brain-derived neurotrophic factor (BDNF), which, in combination with the mammalian target of rapamycin (mTOR), promotes the growth of new neural connections. This process of neuroplasticity may help redirect the brain away from hyperactive areas associated with negative reward signals, potentially providing long-term relief from depression.

Getting Treatment

Don’t let depression control your life any longer. Our highly trained healthcare providers at Renew Health in Allen, Texas, are here to help you find relief. Our team is dedicated to providing compassionate care and personalized treatment plans to help you regain control of your mental health. If you’re ready to explore ketamine treatment for depression, don’t hesitate to reach out to us. Contact Renew Health today and take the first step towards a brighter tomorrow.

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